Jeremy S Francis Selected Research

Canavan Disease (Leukodystrophy, Spongiform)

12/2016	N-acetylaspartate supports the energetic demands of developmental myelination via oligodendroglial aspartoacylase.
5/2014	Dietary triheptanoin rescues oligodendrocyte loss, dysmyelination and motor function in the nur7 mouse model of Canavan disease.
12/2012	Long-term follow-up after gene therapy for canavan disease.
9/2012	Aspartoacylase supports oxidative energy metabolism during myelination.
1/2009	Myelin lipid abnormalities in the aspartoacylase-deficient tremor rat.
11/2005	Simultaneous high performance liquid chromatographic separation of purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis of inborn errors of metabolism.

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Jeremy S Francis Research Topics

Disease

6	Canavan Disease (Leukodystrophy, Spongiform) 12/2016 - 11/2005
2	Tremor (Tremors) 01/2009 - 07/2006
1	Alzheimer Disease (Alzheimer's Disease) 03/2015
1	Neoplasms (Cancer) 07/2014
1	Disease Progression 12/2012
1	Inborn Errors Metabolism (Inborn Errors of Metabolism) 11/2005

Drug/Important Bio-Agent (IBA)

5	EnzymesIBA 12/2016 - 07/2006
4	N-acetylaspartate (N-acetyl aspartate)IBA 12/2016 - 09/2012
4	aspartoacylaseIBA 12/2016 - 07/2006
2	Fatty Acids (Saturated Fatty Acids)IBA 12/2016 - 01/2009
1	GATA6 Transcription FactorIBA 07/2014
1	triheptanoinIBA 05/2014
1	Biomarkers (Surrogate Marker)IBA 12/2012
1	CerebrosidesIBA 01/2009
1	LipidsIBA 01/2009
1	Sulfoglycosphingolipids (Sulfatides)IBA 01/2009
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 07/2006
1	Dicarboxylic AcidsIBA 11/2005
1	N-acetylglutamic acidIBA 11/2005
1	isospaglumic acid (NAAGA)IBA 11/2005
1	Amino Acids FDA Link 11/2005
1	PyrimidinesIBA 11/2005
1	PurinesIBA 11/2005